hahn lab

contact us

Dr. Klaus Hahn
Thurman Professor of Pharmacology
Department of Pharmacology
CB# 7365
UNC-Chapel Hill School of Medicine
Chapel Hill, NC 27599
khahn[at]med.unc.edu

Positions Available

Dr. Hahn always welcomes applications from creative, highly motivated scientists in any area relevant to our work. Right now we are particularly searching for people interested in the starred projects below. To apply, please send a CV and letter describing your goals and research plans to Dr. Hahn at khahn[at]med.unc.edu.

new approaches:

  • Novel designs for biosensors and optogenetics, for new capabilities and to access currently intractable targets
  • Harnessing allosteric networks for engineered control of proteins, including projects combining molecular modeling and application to cell biology
  • Novel reporter dyes and small molecule modulators of protein function, coupled with novel methods for protein labeling in cells. Applicants must be experienced in complex multi-step organic syntheses. These projects offer the opportunity for an organic chemist to move into a new area of research, combining organic synthesis and molecular biology
  • High throughput screening approaches, combined with modeling of protein binding interfaces, to design novel proteins for visualization and control of signaling networks
  • Collaborative projects, interfacing our work in live cell imaging with image analysis laboratories (Danuser- UTSW, Elston-UNC, Tsygankov- Emory/Georgia Tech) and microscope development (Superfine - UNC, Gratton - UCI, Betzig – Janelia Farm).  See ad below for project with Tim Elston of UNC.

biology:

  • Signaling in phagocytosis, investigated using single molecule biosensor imaging and optogenetics
  • Biology of megakaryocytes - platelet production, morphodynamics and motility
  • Systems biology of cell morphodynamics, in collaboration with the Danuser lab (UTSW)
  • Adhesion signaling  in cross cell communication during motility,  and the role of mechanical force in directing cell migration within the tumor microenvironment. Some projects are collaborations with the Keely lab (U. Wisconsin), Nain lab (Virginia Tech) and Burridge/Superfine laboratories (UNC).


Currently advertised postdoc position in image analysis/systems biology of motility:

Postdoctoral Position, Modeling and Image Analysis of Motility Signaling Networks. The Labs of Drs. Tim Elston and Klaus Hahn are seeking a postdoctoral research associate to develop mathematical models and image analysis tools to investigate molecular mechanisms that regulate the spatiotemporal dynamics of signaling during cell migration. The Hahn lab develops engineered proteins to monitor and perturb signaling networks with precise spatiotemporal resolution in living cells and animals.  The goal of this project is to combine these experimental approaches with quantitative image analysis and mathematical models developed in the Elston lab to elucidate signaling networks that coordinate the behavior of different subcellular systems and organelles during migration. This position is funded by a grant through the Army Research Office. Please contact Dr. Elston at telston[at]med.unc.edu or Dr. Hahn at khahn[at]med.unc.edu. UNC-Chapel Hill is located in central North Carolina midway between the coastal island beaches and the Smoky Mountains National Park. It is in a center of academic, biotechnology, and pharmaceutical research, neighboring Duke, NC State, and the Research Triangle.

Our Location

4th Floor Genetic Medicine Building
120 Mason Farm Rd.
UNC-Chapel Hill Campus

Dr. Hahn's Office: 4043 Genetic Medicine
Lab:
4022 Genetic Medicine

Directions & Parking

From Interstate 40 East (from Raleigh, RDU Airport and points east)
From Interstate 85 South (coming from Charlotte, Winston-Salem, Greensboro)
From Interstate 85 North (from Durham and points north)
From 15-501 South (from Pittsboro, Chatham Co. and points south)
From Hwy 54 West (Chatham Co., Orange Co., Allamance Co. and points west)

Maps

Map to Chapel Hill (maps coutesy of MapQuest) Closer Map
Map to Manning Drive and UNC (map courtesy of MapQuest)
Map from Dogwood Parking Deck to Genetic Medicine Building
Google map showing location of Genetic Medicine Building on UNC campus

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