hahn lab

cell cinema

Click link or image to view movies. Chosen simply because they are fun to watch.

Dyes & Dye-based biosensors

Cdc42 activation in RhoA-inhibed cell; meroCBD biosensorCdc42 activation in RhoA-inhibited cell; meroCBD biosensor
by Perihan Nalbant and Louis Hodgson
(Science, 305:1615-1619, 2004.)
Dye on ERK2Merocyanine dye on phospho-ERK2
by Alexei Toutchkine and Brenda Temple

Image and data analysis

Sampling windows track the cell edge for localized assessment of biosensor activity - MOVIE ON THE WAY
developed by our collaborators in the Danuser lab
(Nature, 461: 99-103, 2009.)
Automated tracking of cell morphology over time. Simple 2D trace captures morphodynamics over time - MOVIE ON THE WAY
developed by our collaborators in the Elston and Tsygankov labs
(Proc. Natl. Acad. Sci. U.S.A. 111(34):12420–12425, 2014.)
CellGeo package accurately measures dimensions and morphodynamics of complex cell boundaries - MOVIE ON THE WAY
developed by our collaborators in the Elston and Tsygankov labs
(J. Cell Biol. 204(3): 443-460, 2014.)

Engineered allosteric activities

RapR analogs of Src family kinases. Specific activation of the closely related family members Fyn, Src, and Lyn produces different cell phenotypes (Fyn-spreading; Src-spreading followed by movement; Lyn-surprising kinked extensions) - MOVIE ON THE WAY
by Pei Hsuan Chu
(Proc. Natl. Acad. Sci. U.S.A. 111(34):12420–12425, 2014.)

Miscellaneous

Cytotoxic lymphocyte killing a virall yinfected fibroblastCytotoxic lymphocyte killing a virally infected fibroblast (oldie but goodie)
by Klaus Hahn, Robin DeBiasio, Greg LaRocca, D. Lansing Taylor, and Michael Oldstone
(Virology, 201(2):330-340, 1994.)
Retroactive transport movieRetrograde Transport
by Noah Sciaky

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