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Photomanipulation of proteins in vivo
Moving laser spot induces Rac1 activation and consequent cell protrusion by Yi Wu
(Nature, 461: 104-110, 2009.)
Pulses of light on one spot along the cell edge (red circle) activate Rac1 locally, producing first ruffles and then a protrusion. by Yi Wu
(Nature, 461: 104-110, 2009.)
Cells in living zebrafish spelling "Rac" by our collaborators, Sa Kan Yoo and Qing Deng in the Huttenlocher Lab
(Dev Cell, 18: 226-23, 2010.)
NIGMS Biomedical Beats:" Cool video: Leading Cells with light."with captions and narration by NIH, images by Yi Wu
(NIGMS Biomedical Beats, Sept.2009 issue.)
FLARE genetically encoded biosensors
RhoA activation (left) versus localization (right) in a moving fibroblast (ver.1) by Olivier Pertz and Louis Hodgson
(Nature, 440(7087):1069-1072, 2006.)
Dyes & Dye-based biosensors
Cdc42 activation in RhoA-inhibited cell; meroCBD biosensorby Perihan Nalbant and Louis Hodgson
(Science, 305:1615-1619, 2004.)
Src activation in macropinocytic vesicles.by Akash Gulyani
(Nat Chem Biol. 2011 Jun 12;7(7):437-44. )
High content screening
Cell tracking and cell division, 37 hoursby Feimo Shen and Louis Hodgson
(Cytometry, Vol. 69, No. 7, 2006, 563-572, © 2006 International Society for Analytical Cytology. Reprinted with permission of Wiley-Liss, Inc., a subsidiary of John Wiley & Sons.)
Engineered allosteric control of proteins
Activation of RapR FAK generates dorsel ruffles.by Andrei Karginov
(Nature Biotechnology, 28:743-748, 2010.)
Miscellaneous
Cytotoxic lymphocyte killing a virally infected fibroblast by Klaus Hahn, Robin DeBiasio, Greg LaRocca, D. Lansing Taylor, and Michael Oldstone
(Virology, 201(2):330-340, 1994.)
