hahn lab

cell cinema

Click link or image to view movies.

Zebrafish spelling RacCells in living zebrafish spelling "Rac"
by our collaborators, Sa Kan Yoo and Qing Deng in the Huttenlocher Lab
(Dev Cell, 18: 226-23, 2010.)
cool movieNIGMS Biomedical Beats:" Cool video: Leading Cells with light."
with captions and narration by NIH, images by Yi Wu
(NIGMS Biomedical Beats, Sept.2009 issue.)

FLARE genetically encoded biosensors

RhoA activation (left) versus localization (right) in a moving fibroblast RhoA activation (left) versus localization (right) in a moving fibroblast
by Olivier Pertz and Louis Hodgson
(Nature,  440(7087):1069-1072, 2006.)

Dyes & Dye-based biosensors

Cdc42 activation in RhoA-inhibed cell; meroCBD biosensorCdc42 activation in RhoA-inhibited cell; meroCBD biosensor
by Perihan Nalbant and Louis Hodgson
(Science, 305:1615-1619, 2004.)
Dye on ERK2Merocyanine dye on phospho-ERK2
by Alexei Toutchkine and Brenda Temple
Dye on ERK2Src activation in macropinocytic vesicles.
by Akash Gulyani
(Nat Chem Biol. 2011 Jun 12;7(7):437-44. )

High content screening

Cell tracking and cell division, 37 hours Cell tracking and cell division, 37 hours
by Feimo Shen and Louis Hodgson
(Cytometry, Vol. 69, No. 7, 2006, 563-572, © 2006 International Society for Analytical Cytology. Reprinted with permission of Wiley-Liss, Inc., a subsidiary of John Wiley & Sons.)

Engineered allosteric control of proteins

Cell tracking and cell division, 37 hours Activation of RapR FAK generates dorsal ruffles.
by Andrei Karginov
(Nature Biotechnology, 28:743-748, 2010.)

Activation of RapR-Src generates focal adhesion rearrangements
by Andrei Karginov
(Nature Chem Bio, March 9, 2014 doi:10.1038/nchembio.1477.)


Cytotoxic lymphocyte killing a virall yinfected fibroblastCytotoxic lymphocyte killing a virally infected fibroblast
by Klaus Hahn, Robin DeBiasio, Greg LaRocca, D. Lansing Taylor, and Michael Oldstone
(Virology, 201(2):330-340, 1994.)
Fibroblast MotilityFibroblast Motility
by Feimo Shen
Retroactive transport movieRetrograde Transport
by Noah Sciaky

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